Lupiañez Lab 3D Genomics

Publications

See our highlighted publications

Complete male-to-female sex reversal in XY mice lacking the miR-17 92 cluster
Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster
Alicia Hurtado, Irene Mota-Gómez, Miguel Lao, Francisca M. Real, Johanna Jedamzick, Miguel Burgos, Darío G. Lupiáñez, Rafael Jiménez, Francisco J. Barrionuevo
Nature Communications  ·  07 May 2024  ·  doi:10.1038/s41467-024-47658-x

The little skate genome and the evolutionary emergence of wing-like fins
The little skate genome and the evolutionary emergence of wing-like fins
Ferdinand Marlétaz, Elisa de la Calle-Mustienes, Rafael D. Acemel, Christina Paliou, Silvia Naranjo, …, Tetsuya Nakamura, Juan J. Tena, Darío G. Lupiáñez, Daniel S. Rokhsar, José Luis Gómez-Skarmeta
Nature  ·  12 Apr 2023  ·  doi:10.1038/s41586-023-05868-1

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation
In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation
Chiara Anania, Rafael D. Acemel, Johanna Jedamzick, Adriano Bolondi, Giulia Cova, Norbert Brieske, Ralf Kühn, Lars Wittler, Francisca M. Real, Darío G. Lupiáñez
Nature Genetics  ·  01 Jul 2022  ·  doi:10.1038/s41588-022-01117-9

The mole genome reveals regulatory rearrangements associated with adaptive intersexuality
The mole genome reveals regulatory rearrangements associated with adaptive intersexuality
Francisca M. Real, Stefan A. Haas, Paolo Franchini, Peiwen Xiong, Oleg Simakov, …, Axel Meyer, Martin Vingron, Rafael Jiménez, Stefan Mundlos, Darío G. Lupiáñez
Science  ·  09 Oct 2020  ·  doi:10.1126/science.aaz2582

Structural variation in the 3D genome
Structural variation in the 3D genome
Malte Spielmann, Darío G. Lupiáñez, Stefan Mundlos
Nature Reviews Genetics  ·  24 Apr 2018  ·  doi:10.1038/s41576-018-0007-0

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh Indian hedgehog
Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)
Anja J Will, Giulia Cova, Marco Osterwalder, Wing-Lee Chan, Lars Wittler, …, Martin Vingron, Eva Klopocki, Axel Visel, Darío G Lupiáñez, Stefan Mundlos
Nature Genetics  ·  28 Aug 2017  ·  doi:10.1038/ng.3939

Breaking TADs: How Alterations of Chromatin Domains Result in Disease
Breaking TADs: How Alterations of Chromatin Domains Result in Disease
Darío G. Lupiáñez, Malte Spielmann, Stefan Mundlos
Trends in Genetics  ·  01 Apr 2016  ·  doi:10.1016/j.tig.2016.01.003

Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions
Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions
Darío G. Lupiáñez, Katerina Kraft, Verena Heinrich, Peter Krawitz, Francesco Brancati, …, Bernd Timmermann, Jochen Hecht, Malte Spielmann, Axel Visel, Stefan Mundlos
Cell  ·  01 May 2015  ·  doi:10.1016/j.cell.2015.04.004

Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR Cas in Mice
Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice
Katerina Kraft, Sinje Geuer, Anja J. Will, Wing Lee Chan, Christina Paliou, …, Bjørt K. Kragesteen, Malte Spielmann, Stefan Mundlos, Darío G. Lupiáñez, Guillaume Andrey
Cell Reports  ·  01 Feb 2015  ·  doi:10.1016/j.celrep.2015.01.016